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Moreover, IL-12 sensitizes neoplasms toward checkpoint inhibitors like PD-1/PD-L1 blockade, thereby amplifying therapeutic efficacy (80)

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Further studies revealed that the effect of SYD was attributed to its role in activating mitogen-activated protein kinase phosphatase-1 (MKP1) since MKP1 inhibitor would suppress the protective role of SYD on colonic changes induced by DSS